How the Intestinal Permeability Test Checks for Leaky Gut:
This test involves ingesting in two sugars, lactulose, and mannitol. Lactulose should not be able to be absorbed through your gut wall. The test then analyzes your urine for the presence of those two sugars. If lactulose is present in your urine, then it has leaked through the gut wall into your blood. It has been carried to your kidneys for excretion through the urine.
Signs You Need This Test:
- Food sensitivities
- Autoimmune diseases
- Joint Pain
- Nutritional deficiencies
What it Tells Us:
It identifies “leaky gut” and malabsorption problems.
By Dr. Pamela Frank, Naturopathic Doctor, updated Jan. 4, 2020
Research on the Lactulose-Mannitol Test for Leaky Gut
Kumar D1, Pandey G2, Bansal D2, Rawat A1,3, Kumar U1, Dubey D1,3, Guleria A1, Saraswat VA2.NMR-based urinary profiling of lactulose/mannitol ratio used to assess the altered intestinal permeability in acute on chronic liver failure (ACLF) patients. Magn Reson Chem. 2017 Apr;55(4):289-296. doi: 10.1002/mrc.4525. Epub 2016 Sep 29.